Site Name: USA - Pennsylvania - Upper Providence
Posted Date: Apr 6 2023
Are you looking for an exciting postdoctoral fellowship in the pharmaceutical industry? Are you passionate about in vitro disease modelling and have an interest in learning more about oligo-related therapeutics? If so, this postdoc role could be an exciting opportunity for you to consider. As a postdoctoral researcher at GSK, you will be focused on addressing the critical R&D challenges that have been selected as cutting-edge science. Your experience will be accompanied by tremendous support at GSK with the opportunity to work for daily collaborations with world-class scientists. In this project, you\xe2\x80\x99ll be responsible for driving a project focused on NASH-related genes amenable for oligo-related therapeutics. This postdoctoral researcher will drive a project focused on identification of NASH-related genes and isoforms amenable for RNA splicing modulation. The postdoc in this role will characterize human cell models (including cell lines, primary cells) using standard assays and \xe2\x80\x98omics-based approaches to identify candidate genes with nonsense-mediated RNA isoforms. From this, the postdoc will then execute target validation experiments including genetic perturbation to identify a prioritized target for a subsequent screen to identify oligonucleotide hits for target up-regulation. This is a project that will allow the postdoc to participate in driving and executing cutting edge research and technology in advanced cellular models and RNA therapeutics at GSK. This postdoc will gain practical experience including performing research in an industrial setting, partnership with subject matter experts at GSK to enable project success, exposure to project management, and glimpses into the drivers behind decision making in the pharmaceutical industry. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following\xe2\x80\xa6
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