Job Description

At Horizon Therapeutics, we define success by the number of lives touched, lives changed, and lives saved. Our global biotechnology company is made up of agile, out-of-the-box thinkers with a focus on delivering breakthrough medicines to those living with rare, autoimmune, and severe inflammatory diseases. This is the heart of our global mission. Start a career that enables you to live up to your potential and help others live up to theirs. Join us.

The exceptional support we provide patients and communities equally extends to our employees. We offer industry-leading and award-winning benefits, compensation and rewards programs that positively impact all areas of our employees\' personal and professional lives.

Position Summary

As an Associate Director Translational Medicine Lead, you\'ll play an important role in designing, executing and analyzing biomarker data from Horizon interventional clinical trial and observational academic collaborations to deliver scientific insights on our molecules. As the Translational Medicine representative on cross-functional drug development teams for late clinical stage molecules you are responsible for bringing the scientific insights into pharmacodynamics and target engagement, mechanism of action and responder populations for our portfolio of immunomodulating molecules.

Responsibilities:

• Develop and execute translational strategies to achieve project-specific goals and objectives for investigational therapeutics in clinical development.
• Represent the Translational Medicine function in cross-functional drug development teams.
• Work within a matrixed, cross functional team to provide end to end oversight of biomarker sample collection, testing and analysis.
• Initiate and oversee contracting and sample analysis with CROs to execute biomarker testing plans.
• Track budgets and deliverables.
• Establish fit for purpose biomarker assays internally or with third party vendors.
• Evaluate new technologies and assay platforms for clinical biomarker use.
• Guide data analyses in collaboration with Biometrics and Quantitative Biology colleagues to deliver informative analyses to support internal decision making, regulatory interactions and publications/abstracts.
• Collaborate with Research and Commercial and Medical Affairs to provide scientific input into new disease indications under consideration
• Collaborate with academics to initiate and carry out Ph0 studies or collaborations to generate disease relevant biomarker data and insights into biomarker defined patient subgroups and endotypes.

Qualifications and Skills Required

• PhD in immunology or relevant scientific discipline; minimum PhD +7-10year (or BSc + 15 year, MSc +13 year)
• A calling to develop new therapies for patients with inflammatory diseases.
• A broad understanding of cellular and molecular pharmacology concepts within the autoimmunity and/or immunology field is essential.
• Ability to work in a fast-paced environment with rapidly changing and competing priorities and ambiguity.
• Prior experience with clinical trials preferred but not essential
• Hands on experience with clinical assays and assay development
• Familiarity with a variety of biomarker assay platforms
• Establish fit for purpose biomarker assays internally or with third party vendors
• Willingness to perform lab work when necessary
• Prior experience analyzing big data
• Detailed orientated approach
• Good planning, organization, and project management skills
• Proficient in Microsoft Office.
• Professional, proactive demeanor.
• Strong interpersonal skills.
• Excellent written and verbal communication skills.

Our Values

• Transparency: We value collaboration. Trusting teach other and tackling tough challenges can make a powerful difference.
• Accountability: We do what\'s right for our patient communities through quality decisions and owning our successes and failures.
• Growth: We fiercely innovate and evolve to better ourselves, our communities and our patients.

These three values come to life through our five Leadership Expectations that apply to all Horizon employees

• Enterprise Mindset: Look beyond one\'s team, brand or function to see the broader company and external perspective
• Exhibit Intellectual Curiosity: Seek to understand what you do not know; ask the right questions of the right people and sources
• Ensure Accountability and Courage: Step up to address difficult issues and hold self and others accountable to commitments
• Embrace Diverse Perspectives: Welcome others with a respectful attitude; integrate diverse perspectives into ways of working
• Develop Talent: Provide feedback, coaching and mentorship to help others be more effective in their role

At Horizon, we know that disease does not discriminate. We embrace the bold ideas of one another, foster a sense of belonging, and value inclusion. We attract and develop diverse talent because we believe that when people from different backgrounds and life experiences come together, we make lives better.

Horizon intends that all qualified applications are given equal opportunity, and that selection decisions be based on job-related factors. We do not discriminate based on race, color, religion, gender, sexual orientation, national origin, age, disability, veteran status, or any other characteristics protected by law.

Horizon Therapeutics