Job Description

Why Mayo Clinic

Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.

Benefits Highlights

Medical: Multiple plan options. Dental: Delta Dental or reimbursement account for flexible coverage. Vision: Affordable plan with national network. Pre-Tax Savings: HSA and FSAs for eligible expenses. Retirement: Competitive retirement package to secure your future.

Responsibilities

The Translational Neuroproteomics Laboratory, directed by Dr. Wilfried Rossoll, is seeking a highly motivated and detail-oriented project associate to join our team in the Department of Neuroscience. Our group investigates how abnormal protein aggregation drives neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer's disease (AD), and related proteinopathies.



Our research combines state-of-the-art mass spectrometry-based proteomics, advanced fluorescence microscopy, and a range of molecular and cellular approaches to define the molecular composition of disease-associated protein aggregates. We focus primarily on TDP-43 and tau, key pathological proteins in ALS, FTD, and AD, while also studying related aggregates such as ?-synuclein in Parkinson's disease and Lewy body dementia. By identifying molecular drivers and modifiers of aggregation, our goal is to uncover new therapeutic targets and develop strategies to slow or prevent disease progression.

Using insights gained from proteomic and mechanistic studies, our team conducts experiments in cellular and animal models to determine how aggregates form, spread, and cause toxicity. These studies directly support our broader mission of developing and validating therapeutic approaches for neurodegenerative proteinopathies.


For more information about our research program, please visit:

https://www.mayo.edu/research/labs/translational-neuroproteomics/overview


Responsibilities

We are looking for an enthusiastic individual with a strong interest in neuroscience and a desire to learn new techniques. The ideal candidate will bring curiosity, attention to detail, and basic laboratory and computer skills. Experience with molecular biology, cell biology, or biochemical methods is advantageous. We offer a supportive, collaborative environment with individualized training, mentorship, and opportunities for career development.


The successful candidate will perform diverse laboratory tasks, including:

Immunohistochemistry on cultured cells and tissue sections Mammalian cell culture Fluorescence microscopy Protein affinity purification and biochemical assays Sample preparation for mass spectrometry General laboratory support, record-keeping, and data organization
The position is considered non-exempt (hourly), and therefore, all hours worked must be recorded. A Special Project Associate at Mayo Clinic is a temporary position intended to execute experimental studies in support of lab goals and grant commitments as designated by the Principal Investigator. Performs basic statistical data analysis; prepares tables, charts/graphs and assists in organizing data; completes assorted laboratory procedures and assays. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic.


The following is required for completeness of application: Current curriculum vitae with bibliography, Proof of highest degree received (if awarded a Bachelor's or Master's degree). Please also be prepared that you may be asked to provide two letters of recommendation to the hiring PI prior to an interview.

Qualifications

B.S. in Biology, Neuroscience, Biochemistry, or a related field For J-1 visa sponsorship, a Master's degree is required Prior experience in molecular biology, cell biology, or biochemistry is an advantage Must have a solid understanding of lab techniques, equipment, and safety.

Exemption Status

Nonexempt

Compensation Detail

$25.19 - $33.15 / hour; Education, experience and tenure may be considered along with internal equity when job offers are extended.

Benefits Eligible

Yes

Schedule

Full Time

Hours/Pay Period

80

Schedule Details

Varies

Weekend Schedule

Varies

International Assignment

No

Site Description

Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.

Equal Opportunity

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law". Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.

Recruiter

Amy Hoffman