Job Description

Senior Scientist, Translational Pathology

Waltham, MA

We are seeking a Senior Scientist to join the Translational Pathology group in Oncology R&D. You will be at the forefront of the evolution of translational science and cancer biomarker development at AstraZeneca! You will have the opportunity to impact an industry-leading portfolio of programs from early clinical development of novel therapeutics through to post-marketing opportunities that support approved targeted therapies.

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people\xe2\x80\x99s exceptional skills with those of people from all over the globe!

Major Responsibilities and Accountabilities:

In this role you will have the opportunity to participate in the establishment of a new laboratory at the AstraZeneca Boston, USA site. As part of this role, you will be working with our expanding Translational Genomics and Haematology teams to provide histology and pathology support. Our Global Genomics team uses bulk and single cell DNA and RNA sequencing methods along with a variety of spatial technologies to match the right patient to the right drug and to support precision oncology approaches for the AstraZeneca Oncology pipeline. This role will require you to use the best available science, technology and digital AI to work alongside our genomics team and translational pathologists, bridging the two teams. As well as ensuring delivery of high-quality tissue specimens with tumor annotations for greater precision of nucleic acid extraction, including support of our single cell applications.

Skills and experience:

• BSc/MSc degree in a relevant science subject and 2 years of experience in industry/a relevant field
• Experience working with human tissue samples and tissue-based histopathology methods, including microtomy skills.
• Experienced in microscopy and/or digital slide scanning, particularly examination of human pathology samples.
• Ability to work effectively within a multi-disciplinary team environment and multi-task in a fast-paced environment with changing priorities.
• Familiarity with and commitment to safe laboratory practices.
• Ability to lead from the bench in problem solving and the development of innovative solutions.

Desirable/Advantageous \xe2\x80\x93 Although training will be given, experience in the following areas would provide a distinct advantage:

• PhD in a relevant field
• Knowledge of cancer biology and associated mutational drivers/ tumour suppressors.
• Familiarity with Next Generation Sequencing techniques such as whole exome/genome sequencing, large pan-cancer enrichment panels and whole transcriptome.
• Experience extracting nucleic acids from formalin fixed paraffin embedded tissues.
• Experience in macro-dissection of tissue from histology slides.
• Experience with manual and/or automated immunohistochemistry (IHC) or immunofluorescence (IF).
• Experience in digital image analysis.
• Experience in flow cytometry
• Peer-reviewed publications in the field of translational pathology or cancer biology.
• Experience working with a LIMS and electronic lab notebook.

About the Waltham Site

Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park BioHub, just west of the city center. Our BioHub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world\xe2\x80\x99s most vibrant research centers.

Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you\xe2\x80\x99ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community.

As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here:

So, what\xe2\x80\x99s next-

Are you already envisioning yourself joining our team? Good! We can\xe2\x80\x99t wait to hear from you!

If you\xe2\x80\x99re curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Closing Date: August 28, 2023

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Date Posted 13-Aug-2023

Closing Date 27-Aug-2023

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

AstraZeneca