Job Description

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.


We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.


The Senior Scientist, Toxicology will lead late clinical stage small molecule programs as well as early, FIH, and late-stage safety strategies for large molecule and conjugated oligonucleotide programs while working in close collaboration with colleagues in Research and Development Sciences.

Key Accountabilities/Core Job Responsibilities

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Provide safety representation on project teams Assess safety of drug targets (Target Safety Assessments) Design and implement in vitro lead optimization strategies in collaboration with chemistry, biology, LMPK, and pharmacology colleagues Understanding of relevant regulatory guidelines Develop IND-enabling nonclinical safety strategies for clinical candidates in development in collaboration with chemistry, biology, LMPK, regulatory, and clinical colleagues Design and oversee non-GLP and GLP toxicity studies for tool or candidate molecules Lead mechanistic or investigative toxicology studies as needed Review comprehensive toxicological data and reports, present findings to internal and partnered stakeholders, and communicate complex scientific concepts clearly to non-toxicology audiences. Conduct risk assessments for clinical trials and provide recommendations for clinical start dose, high dose, and monitoring. Author regulatory documents including Investigator Brochures and relevant Nonclinical Overviews and Summaries in regulatory filings.

Qualifications/Skills

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DVM or PhD in Toxicology, Biology, Pharmacology or related scientific discipline At or near 5 years of relevant work experience working with small molecules, biologics, or oligonucleotides inclusive of postdoctoral experience if applicable DABT preferred Strong scientific background and aptitude Excellent critical thinking and scientific skills Ability to work effectively and collaboratively on cross-functional projects teams, with a demonstrated willingness to take on challenges with positive disposition Excellent oral, presentation, and written communication skills

Salary Range: $138,000.00 to $174,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers
This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.



Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.