Job Description

Senior Scientist, Formulation Development

Syntis Bio is a clinical-stage biopharmaceutical company developing oral therapies that harness the small intestine's unique biology to provide more accessible, effective and sustainable solutions across the healthcare spectrum, from rare genetic disorders to the world's most prevalent conditions. Syntis is rapidly advancing a pipeline of oral therapies engineered for optimization in the small intestine, the body's nexus for metabolic control, digestion and drug absorption. The company's lead program, SYNT-101, is a once-daily oral pill for the treatment of obesity that mimics the effects of gastric bypass surgery. SYNT-101 leverages the power of SYNT(TM) (

SYN

thetic

T

issue-lining), an oral technology developed by Syntis founders that delivers a safe, transient polymer coating to the duodenum that controls nutrient uptake, as well as enhances both gut-restricted enzyme efficacy and systemic drug absorption for up to 24 hours. The company is also developing a portfolio of enzyme replacement therapies to treat orphan metabolic and broad digestive disorders. Syntis is headquartered in Boston and has raised $15.5 million to date from leading life sciences and strategic investors. For more information, please visit www.syntis.bio and follow us on LinkedIn.

Your Impact at Syntis Bio:

We are seeking a

Senior Scientist

to develop and optimize solid oral dosage forms for a platform technology for improved treatment of several therapeutic indications. The Senior Scientist will develop formulation-function relationships to allow for formulation optimization. In addition, this Senior Scientist will work with the regulatory, in vivo, and clinical teams, as well as external partners. The role will involve clearly presenting technical information to both a technical audience and non-technical audience. The role is on-site and located in Dorchester in Boston, MA.

The Responsibilities:

Lead development of formulations with Syntis Bio's SYNT technology which incorporates a mucoadhesive polymer for treatment of multiple indications. Propose new formulation strategies for optimal performance, production, and stability particularly for drugs with poor oral bioavailability. Develop deep understanding of how formulation affects various aspects of function such as dissolution and permeability through optimization of in vitro characterization assays, ex vivo tissue-based assays, and in vivo animal studies. Support CMC sections of regulatory filings including INDs, BLAs, and NDAs Interpret, analyze, present, and properly record data. Proactively seek opportunities to enhance our SYNT technology and other platforms through cross-functional collaboration with our internal and external research teams. Stay at the forefront of formulation innovations, proactively incorporating emerging tools and technologies to enhance team capabilities. Prepare documents and presentations that encompass project progression. Perform job related duties as assigned.

The Ideal Skills:

PhD in bioengineering, materials science, formulation sciences, pharmaceutical sciences, chemical engineering or equivalent relative experience and a minimum of 5+ years of industry experience. Understanding of polymer chemistry as it pertains to coating in solid dosage forms. Excited by and scientifically driven to overcome complex technical challenges that are impacted by multiple drug delivery factors. Deep experience with the development of solid oral dosage forms and the unit operations for production. Experience with the development of strategies to improve the oral bioavailability of molecules with low permeability (Ex. BCS Class III/IV, peptides) Deep understanding of the gastrointestinal barriers that limit drug absorption. Experience collaborating or working with the execution of studies utilizing animal models is a plus. Strong record of deliberate mentorship or management of junior level staff. Proven ability to lead the scientific direction of a project. Strong written and oral communication skills for technical and non-technical audiences. Conscientious team member with experience taking and giving constructive feedback.

Syntis Bio is pleased to offer:

Medical, Dental, and Vision health plans.

Flexible time off.

Commuter transit plan.

Flexible Spending Account plan.

401(k) retirement plan.

STD, LTD, Life insurance plans.

Job Type: Full-time

Pay: $150,000.00 - $165,000.00 per year

Benefits:

401(k) Dental insurance Flexible schedule Health insurance Life insurance Paid time off Parental leave Vision insurance
Application Question(s):

Do you have a minimum of 5 years of relevant industry experience in the areas of bioengineering, materials science, formulation sciences, pharmaceutical sciences, or chemical engineering ?
Education:

Doctorate (Required)
Ability to Relocate:

Boston, MA 02125: Relocate before starting work (Required)
Work Location: In person