Job Description

Position Overview

The Large Molecule Research (LMR) department is seeking a highly motivated candidate to join the Biologics Characterization, Expression, and Purification (BiCEP) team. The scientist will work closely with other LMR functional groups (Protein Engineering, Antibody Discovery, Molecular Biology and Screening) as well as the therapeutic areas. The successful candidate will play a key role in the discovery of new therapeutic antibodies. The position is located in Cambridge, Massachusetts

Key Responsibilities

Express and purify recombinant antibodies, antigens, and fusion proteins to support early-stage antibody discovery research

Perform analytics to ensure the purity, quality, and function of recombinant proteins

Initiate, design, and perform platform improvement experiments

Work with scientists of therapeutic teams and other departments, and maintain a culture of teamwork and collaboration in cross-functional project teams

Present data to department and project teams

Provide mentoring and training to new and junior colleagues

Qualifications

PhD in Biochemistry, Biotechnology, Biology, Biomedical Engineering or a related field. Master\xe2\x80\x99s degree with a minimum of 5 years\xe2\x80\x99 relevant experience will also be considered

Demonstrated ability to independently design, execute, and present experimental results

Experience with transient and stable mammalian protein expression

Experience in protein purification using automated (AKTA) systems

Experience with protein analytical techniques, such as HPLC, mass spectrometry, SPR (Biacore/Carterra), BLI (Octet), SDS-PAGE, ELISA, Western blotting

Excellent organizational and communication skills; ability to present findings to diverse scientific groups in clear and concise manner

Strong analytical and problem-solving skills

Preferred Qualifications

Experience with multiple protein expression systems (i.e. yeast, bacteria, engineered cell lines), including troubleshooting difficult-to-express proteins

A background in biochemistry or biophysics for the generation and purification of complex antibodies and/or antigens or non-antibody formats

Experience with protein and antigen design using sequence and structure analysis as well as purification of constructs with appropriate tags

Expression and purification of non-standard antibodies such as bi- and tri-specific antibodies and higher valency formats

Track record of scientific accomplishments as evidenced by publications/patents, including expertise in biochemistry or biophysics

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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