Job Description

Description :
The HPC Scientific System Architect will be responsible for designing, optimizing, and maintaining high-performance computing (HPC) infrastructure tailored to genomic and scientific workflows. This senior-level role requires deep expertise in HPC architecture, bioinformatics workflows, and system performance tuning. The architect will collaborate with cross-functional teams--including scientists, software engineers, and bioinformaticians--to ensure the infrastructure meets the demanding computational needs of genomic analysis and clinical applications.
RESPONSIBILITIES:
HPC Architecture and System Design:

• Design scalable HPC systems and environments tailored to Baylor Genetics' scientific computing requirements.

• Advise on and assist in selecting appropriate hardware based on the performance needs of genomic tools and workflows.

• Architect hybrid and cloud-based HPC solutions aligned with scientific and operational goals.

Workflow Optimization and Performance Tuning:

• Collaborate with bioinformatics teams to optimize workflows using job schedulers (e.g., Slurm) and workflow managers (e.g., Nextflow).

• Tune software and system parameters to enhance performance of bioinformatics and other scientific workloads.

• Analyze genomics workflows to identify bottlenecks and recommend architectural or software improvements for optimization on the HPC system.

System Administration and Configuration Management:

• Architect solutions for configuration management and deployment of bioinformatics software.

• Advise on HPC administration, including storage systems, data management strategies, and monitoring tools.

• Provide guidance on security and compliance practices for handling sensitive genomic data.

Cross-Functional Collaboration:

• Work closely with scientists, software engineers, and bioinformaticians to align infrastructure with analysis and clinical needs.

• Support DevOps and IT teams in deploying and maintaining HPC systems and services.

Regulatory and Compliance Support:

• Ensure HPC systems and workflows comply with regulatory standards such as CLIA, CAP, HIPAA, and FDA.

• Assist in documenting HPC-related processes and support audits as needed.

QUALIFICATIONS:
Skills:

• Deep knowledge of HPC architecture and design, especially in genomics and bioinformatics contexts.

• Advanced proficiency with Slurm, Bright Cluster Manager, and workflow engines such as Nextflow.

• Hands-on experience of Linux/Unix systems, parallel file systems, and containerization (e.g., Docker, Singularity).

• Excellent problem-solving, communication, and documentation skills.
• Ability to work independently and lead technical initiatives in a fast-paced environment.

Education:

• Bachelor's degree or higher in Computer Science, Engineering, Bioinformatics, or a related field.

Experience:

• Minimum of 5 years of experience in HPC system architecture or administration.
• Proven experience optimizing bioinformatics workflows on HPC systems.
• Experience in healthcare or genomics environments with high regulatory requirements is preferred.

Skills Required