Job Description

Job Summary

Evozyne is an AI-driven protein engineering company developing novel protein therapeutics across a wide range of diseases.


As the Director, Pre-Clinical Drug Development, you will lead the design and execution of preclinical drug development and program management for multiple therapeutic programs working toward IND filing. Reporting to the Chief Operating Officer, you will leverage your deep experience in drug discovery, strong strategic and operational judgment, and excellent communication skills to drive clarity and momentum.

Location:

Remote

What You'll Do

Design pre-clinical drug development plan, including pharmacology, toxicology, and CMC, for protein-based therapeutics to drive multiple programs from engineered candidates to IND. Develop and maintain integrated project plans with clear responsibilities and interdependencies. Execute preclinical project plans to ensure goals and objectives are met, while balancing speed, costs, and risk mitigation. Identify, establish, and manage collaborations with external partners (CROs, CDMOs) to execute preclinical plans and generate high-quality data in compliance with GLP standards. Develop study protocols, pharmacokinetic (PK)/toxicokinetic (TK), pharmacodynamic (PD), and toxicology data for preclinical studies. Analyze results from preclinical studies and contribute to interpretation of results for program decision-making. Actively contribute to scientific and development strategies in exploring new therapies and intellectual property. Manage budget and accrual tracking of executed preclinical investigations Maintain a current awareness of evolving technologies and scientific developments that could be applied to advance programs and contribute to diligence efforts.

Who You Are

You thrive in the dynamic, fast-paced world of an early-stage start-up, where your agility and expertise fuel high-impact results. With deep knowledge of pre-clinical drug development -- especially in the autoimmune space -- you bring a blend of technical know-how and operational savvy to push assets toward the clinic. You're driven by a patient-first mindset and excel at turning complex ideas into clear, actionable strategies that align teams and keep everyone moving forward together.

Required Skills

Minimum 8+ years (Ph.D.), 10+ years (Master's), or 15+ years (Bachelor's) of preclinical research & development experience related to pharmacology, pharmacokinetics, and/or toxicology. Experience in CRO/CDMO oversight and vendor management, including technical, regulatory, and quality aspects. Deep understanding of the drug development process, particularly from discovery through IND filing, including detailed knowledge of GLP, ICH guidelines and current US FDA regulations related to preclinical requirements. Track record of managing multiple IND campaigns in biologics. Protein biologics experience desired. Highly effective influencer without authority at all levels Performs well in a fast-paced, rapidly evolving environment

Education:

Advanced degree (e.g., PhD, PharmD, or Master's) in biology, pharmacology, toxicology, or related field strongly preferred.

Additional Information

The annual base salary for this role is $175,000-$195,000. This is a good faith estimate of the pay range for this position and offers will ultimately be determined based on various factors, including but not limited to, relevant work experience, skills, education, and certifications. As such, final compensation may fall outside of this range. This position will also be eligible for a discretionary bonus.


Evozyne offers a comprehensive benefits package, including group medical, dental and vision insurance, emotional health support, 401k, short and long-term disability, life and AD&D insurance, and flexible spending accounts.